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LORECIVIVINT OSTEOARTHRITIS DRUG PIPELINE – MARKET INSIGHTS AND FORECASTS UPTO 2032

Lorecivivint Osteoarthritis Drug Pipeline: 7 Major Market’s Analysis (Market Size of Lorecivivint in the 7 Major Markets for Osteoarthritis) Country Analysis (Japan, Germany, United States, France, Italy, Spain, United Kingdom)

REPORTS » PHARMACEUTICALS » LORECIVIVINT OSTEOARTHRITIS DRUG PIPELINE – MARKET INSIGHTS AND FORECASTS UPTO 2032

MARKET OVERVIEW

Lorecivivint (SM04690) is a small-molecule inhibitor targeting the Wnt pathway, delivered through intra-articular injection, and is being explored as a potential disease-modifying osteoarthritis drug (DMOAD). Preclinical studies with vehicle-controlled models suggest that lorecivivint may act through a dual mechanism, providing three key benefits for joint health: promoting cartilage regeneration, slowing cartilage degradation, and reducing inflammation. These effects are increasingly important as there is a rising demand for osteoarthritis medication that not only relieves symptoms but also alters the course of the disease.

By inhibiting the nuclear kinases CLK2 and DYRK1A, lorecivivint affects the Wnt pathway, chondrocytes, and inflammatory processes. This dual action indicates that lorecivivint may not only modify osteoarthritis progression by enhancing chondrocyte differentiation and function but also alleviate symptoms through its anti-inflammatory effects. Such advancements could be pivotal for osteoarthritis patients, particularly those with advanced osteoarthritis, who require more effective therapy for osteoarthritis beyond traditional options.

The drug is being developed by Biosplice Therapeutics Inc, a California-based biopharmaceutical company founded in 2008 by Osman Kibar. Biosplice Therapeutics specializes in creating small-molecule therapeutics for various conditions, including osteoarthritis, oncology, and neurology. The company’s innovative platform utilizes alternative pre-mRNA splicing to identify new targets and biological processes that can lead to the development of curative therapies. Their treatments focus on the CLK/DYRK kinase family, which regulates the selection of RNA splice sites unique to certain tissues and diseases. In addition to their work on osteoarthritis, Biosplice Therapeutics is advancing clinical trials in oncology, aiming to inhibit pan-CLK and DYRK kinases.

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MARKET POTENTIAL & POSITIONING

Lorecivivint (LOR), an investigational intra-articular therapy developed by Biosplice Therapeutics, is emerging as a potential breakthrough in knee osteoarthritis (OA) treatment. By targeting the CLK2 and DYRK1A pathways to modulate Wnt signaling, lorecivivint offers a dual mechanism of action that not only alleviates symptoms but also holds promise as a disease-modifying therapy. This innovative approach distinguishes lorecivivint from existing treatments, generating significant anticipation in the OA market.

Currently undergoing Phase III clinical trials, lorecivivint has shown promising results in recent studies OA-07, OA-10, and OA-11. Data from these trials indicate its efficacy in improving both joint structure and patient-reported outcomes, such as pain and function. Notably, the OA-07 study revealed statistically significant improvements in joint structure, pain reduction, and functional enhancement, particularly in patients with early joint damage.

INKWOOD RESEARCH OFFERS AN ANALYSIS OF SEVEN KEY MARKETS

United States
Germany
France
United Kingdom
Italy
Spain
- Osteoarthritis (OA) is a major public health issue in Spain, with its prevalence rising, especially among the aging population. A significant portion of the Spanish population is affected by osteoarthritis, with knee and hip osteoarthritis being the most prevalent forms.
- Women, particularly post-menopause, are more commonly affected by osteoarthritis (OA) than men, reflecting global trends. In Spain, the rising prevalence of OA is driven by an aging population, increased obesity rates, and a higher prevalence of sedentary lifestyles. These factors, along with the chronic nature of osteoarthritis, are placing an escalating burden on Spain’s healthcare system. This situation is leading to a growing demand for effective treatments and interventions that can manage symptoms and enhance the quality of life for those affected.
Japan

INTRODUCTION TO THE REPORT
LORECIVIVINT OVERVIEW
1. PRODUCT DETAIL
2. CLINICAL DEVELOPMENT
  1. CLINICAL STUDIES
  2. CLINICAL TRIALS INFORMATION
  3. SAFETY AND EFFICACY
3. OTHER DEVELOPMENTAL ACTIVITIES
4. PRODUCT PROFILE
COMPETITIVE LANDSCAPE
1. MARKETED THERAPIES
2. LATE-STAGE EMERGING THERAPIES
LORECIVIVINT MARKET ASSESSMENT
1. MARKET OUTLOOK OF LORECIVIVINT IN OSTEOARTHRITIS
7 MAJOR MARKET’S ANALYSIS
1. MARKET SIZE OF LORECIVIVINT IN THE 7 MAJOR MARKETS FOR OSTEOARTHRITIS
2. 7 COUNTRY ANALYSIS
  1. MARKET SIZE OF LORECIVIVINT IN UNITED STATES FOR OSTEOARTHRITIS
  2. MARKET SIZE OF LORECIVIVINT IN GERMANY FOR OSTEOARTHRITIS
  3. MARKET SIZE OF LORECIVIVINT IN FRANCE FOR OSTEOARTHRITIS
  4. MARKET SIZE OF LORECIVIVINT IN ITALY FOR OSTEOARTHRITIS
  5. MARKET SIZE OF LORECIVIVINT IN SPAIN FOR OSTEOARTHRITIS
  6. MARKET SIZE OF LORECIVIVINT IN UNITED KINGDOM FOR OSTEOARTHRITIS
  7. MARKET SIZE OF LORECIVIVINT IN JAPAN FOR OSTEOARTHRITIS
SWOT ANALYSIS
ANALYST PERSPECTIVE

LIST OF TABLES

TABLE 1: LORECIVIVINT, CLINICAL TRIAL DESCRIPTION, 2024

TABLE 2: LORECIVIVINT, GENERAL DESCRIPTION

TABLE 3: MARKETED THERAPIES

TABLE 4: EMERGING THERAPIES

TABLE 5: LORECIVIVINT MARKET SIZE IN THE 7 MAJOR MARKETS, IN $ MILLION (2019–2032)

TABLE 6: LORECIVIVINT MARKET SIZE IN UNITED STATES, IN $ MILLION (2019–2032)

TABLE 7: LORECIVIVINT MARKET SIZE IN GERMANY, IN $ MILLION (2019–2032)

TABLE 8: LORECIVIVINT MARKET SIZE IN FRANCE, IN $ MILLION (2019–2032)

TABLE 9: LORECIVIVINT MARKET SIZE IN ITALY, IN $ MILLION (2019–2032)

TABLE 10: LORECIVIVINT MARKET SIZE IN SPAIN, IN $ MILLION (2019–2032)

TABLE 11: LORECIVIVINT MARKET SIZE IN UNITED KINGDOM, IN $ MILLION (2019–2032)

TABLE 12: LORECIVIVINT MARKET SIZE IN JAPAN, IN $ MILLION (2019–2032)

LIST OF FIGURES

FIGURE 1: LORECIVIVINT MARKET SIZE IN THE 7 MAJOR MARKETS, IN $ MILLION (2019–2032)

FIGURE 2: LORECIVIVINT MARKET SIZE IN UNITED STATES, IN $ MILLION (2019–2032)

FIGURE 3: LORECIVIVINT MARKET SIZE IN GERMANY, IN $ MILLION (2019–2032)

FIGURE 4: LORECIVIVINT MARKET SIZE IN FRANCE, IN $ MILLION (2019–2032)

FIGURE 5: LORECIVIVINT MARKET SIZE IN ITALY, IN $ MILLION (2019–2032)

FIGURE 6: LORECIVIVINT MARKET SIZE IN SPAIN, IN $ MILLION (2019–2032)

FIGURE 7: LORECIVIVINT MARKET SIZE IN UNITED KINGDOM, IN $ MILLION (2019–2032)

FIGURE 8: LORECIVIVINT MARKET SIZE IN JAPAN, IN $ MILLION (2019–2032)

FAQs

What makes Lorecivivint different from other Wnt pathway inhibitors?

A: Lorecivivint stands out because it specifically targets the CLK2 and DYRK1A kinases within the Wnt pathway, which are essential for cartilage repair and inflammation control. This targeted approach sets it apart from other Wnt pathway inhibitors, which may not focus on these particular kinases or possess the same dual mechanism of action.

What are the key challenges in developing Lorecivivint?

A: As with any investigational drug, key challenges include proving consistent efficacy and safety across various patient populations, achieving long-term disease modification, and navigating the regulatory approval process. Moreover, ensuring the treatment is accessible and cost-effective for patients will be crucial.

How does Lorecivivint compare to current standard treatments for knee osteoarthritis?

A: Lorecivivint seeks to address more than just symptom management, which is the primary focus of current standard treatments such as NSAIDs or corticosteroid injections. By potentially modifying the disease’s progression, Lorecivivint could provide a long-term solution for patients.