GLOBAL 3D CELL CULTURE MARKET FORECAST 2019-2027

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GLOBAL 3D CELL CULTURE MARKET FORECAST 2019-2027

The global 3D cell culture market is anticipated to project a CAGR of 12.06% between 2019 and 2027. Maturity in the growth of various assay practices and the predictable advent of 3D optimized protocols, assays, and kits is estimated to deliver hopeful avenues to this vertical, thereby driving the 3D cell culture market in the forthcoming years. The important drivers increasing the growth in the global 3D cell culture market are growing demand for 3D cell culture platforms and technological advancement. 3D cell culture platforms provide an emerging tool to unravel key aspects of any disease state and enable the elucidation of micro-environmental factors supporting in vivo tumour growth.

GLOBAL 3D CELL CULTURE MARKET FORECAST 2019-2027

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The global 3D cell culture market is anticipated to project a CAGR of 12.06% between 2019 and 2027. Maturity in the growth of various assay practices and the predictable advent of 3D optimized protocols, assays, and kits is estimated to deliver hopeful avenues to this vertical, thereby driving the 3D cell culture market in the forthcoming years.

 The global 3D cell culture market is primarily driven by the following factors:

  • Growing demand for 3D cell culture platforms
  • Technological advancement
  • Increased focus on regenerative medicine
  • Rising global R&D investments in cell-based research

The important drivers increasing the growth in the global 3D cell culture market are growing demand for 3D cell culture platforms and technological advancement. 3D cell culture platforms provide an emerging tool to unravel key aspects of any disease state and enable the elucidation of micro-environmental factors supporting in vivo tumour growth. 3D cellular copies are derived using a diversity of scaffolds and structural hydrogels, which in turn aid in increasing revenue generation. However, scholars often encounter predicaments while nurturing 3D cellular models using scaffolds as they hinder cell-to-cell interference and interactions in the assembly of extracellular matrices.

The technology and application of 3D cell culture market are used extensively for various purposes. Scaffold based 3D cell cultures are expected to record lucrative year on year growth owing to the rising demand of 3D cellular model-based research, coupled with the increasing incidence of chronic diseases. Scaffold based is segmented into Hydrogels, Polymeric scaffolds, and Micropatterned Surface Microplates. Scaffolds may interfere with the cell to cell interactions as well as an assemblage of cell produced extracellular matrices as a consequence of which the demand for scaffold-free 3D cell culture products is increasing. Major factors responsible for driving the growth in 3D bioreactor segment include the role of bioreactor based 3D model systems in addressing fundamental scientific questions and the ease of mechanical stimulation and force measurement with the advent of novel products. Cancer-based 3D cell culture market accounts for the biggest share due to the fact that 3D models can mimic the dynamic interplay between tumor and the host environment for assessing the efficacy of drug candidate in cancer patients. The ability of 3D cellular models to abolish the needs of animal model for drug invention and toxicity screening is attributive for the increasing demand for 3D cell culture market which in turn boosts up the revenue generation in this segment. The advantages associated with using the 3D cell culture are improved differentiation behavior and cellular viability, direct transplantation benefits, which include higher cellular loading densities within the transplant, and enhanced graft adherence.

Expenses associated with the Implementation of 3d cell culture and lack of skilled professionals are the major factors hindering the 3D cell culture market. Rising global investment advanced by the government & funding bodies, and the presence of CROs support the using of this technique for cell-based assays. While working on 3D cultures, the professionals face challenges to understand measures, and the whole procedure seems to be time-consuming.

The global 3D cell culture market segments include technology, application, end-user, and component.

Technology is segmented into:

  • Scaffold based
    • Hydrogels
    • Polymeric Scaffolds
    • Micro-patterned Surface Microplates
  • Scaffold Free
    • Hanging Drop Microplates
    • Spheroid Microplates Containing Ultra-Low Attachment (ULA) Coating
    • Microfluidic 3D Cell Culture
    • Magnetic Levitation & 3D Bio-printing
  • 3D Bioreactors

Application is segmented into:

  • Tissue engineering & Immunohistochemistry
  • Cancer
  • Stem Cell Research
  • Drug Development
  • Other applications

End-User is segmented into:

  • Hospitals and Diagnostic Centers
  • Research Laboratories and Institutes
  • Biotechnology and Pharmaceutical Organizations
  • Other end-users

Component is segmented into:

  • Media
  • Reagents and consumables

This report covers the present market conditions and the growth prospects of the global 3D cell culture market for 2019-2027, and considered the revenue generated through the sales of 3D cell culture for technology, application, end-users, and component to calculate the market size by considering 2018 as the base year.

Geographically, the global 3D cell culture market has been segmented on the basis of four major regions, which include:

  • North America: The United States & Canada
  • Asia-Pacific: China, India, Japan, Australia, South Korea & Rest of APAC
  • Europe: The United Kingdom, France, Germany, Italy, Spain & Rest of Europe
  • Rest of World: Africa, Middle East, and Latin America.

The 3D cell culture market in North America is estimated to hold the biggest share by 2027 possibilities of the rising demand for 3D cell culture and market expansion in this area. 3D cell culture technology helps overcome the associated flaws of traditional cell culture as 3D cellular models offer a microenvironment closer to the native human tissue structure. North America 3D cell culture market constitutes approximately 41% share. Furthermore, despite dramatic improvements in therapies, the incidence rate of diseases has risen significantly, which raises the need for advancements in drug invention and development. On the other hand, the Asia-Pacific market is anticipated to the fastest-growing region for the 3D cell culture market. 3D cell culture market of Asia Pacific is estimated to record the fastest growth over the forecast period because of the developing organization in this region fixed with growing awareness about the imminent skills in healthcare amongst the populace.

The 3D cell culture Market is segmented based on end-user which is sub-divided into Biotechnology and Pharmaceutical Organizations, Research Laboratories and Institutes, Hospitals and Diagnostic Centers and other End Users. It is also segmented on the basis of component which is sub-divided into Media and Reagents & Consumables. Biotechnology and pharmaceutical industries were observed to account for the biggest share in of revenue generated and is estimated to record considerable growth in demand in the forthcoming years. 3D cell culture systems are expected to record enhanced demand from hospitals and diagnostic centers owing to the huge benefit offered by 3D models in being more relevant and accurate in cellular environment investigation. The Medias used for 3D cell culture are similar to those used in 2D cell culture but involves the using of several additives and components for growth. Development in 3D cell culture systems is augmented with advanced experiment approach in life science, and advances in cell imaging and analytical systems. Moreover, applications of new scaffolds and matrices are anticipated to generate a lucrative demand for reagents and consumables.

The major market players of the global 3D cell culture market are:

  • Becton, Dickinson and Company
  • Corning Inc.
  • Ge Healthcare
  • Thermo Fisher Scientific Inc.
  • Lonza Group AG

Company Profiles covers the analysis of important players.

BD is actively involved in the development, manufacturing, and distribution of devices, diagnostic products, and laboratory equipment over the globe. BD Medical manufactures medical devices and consumables useful for clinical and hospital uses. The company also manufactures and distributes clinical and research tools such as monoclonal antibodies, FACS, analyzers, and cell culture media for biopharmaceutical manufacturers. Lonza Group AG offers product range in bioresearch, consumer care, Pharma & Biotech, water treatment, agro ingredients, industrial solutions, and wood protection. The company’s market is segmented into Pharma & Biotech and specialty ingredients.

Key Findings of the Global 3D cell culture market:

  • Scaffold free is the fastest growing 3D cell culture technology
  • Stem cell research is a widely used application
  • Biotechnology and pharmaceutical organizations are the major end-users
  • Reagents and consumables are the major used components
  1. RESEARCH SCOPE
    • STUDY GOALS
    • SCOPE OF THE MARKET STUDY
    • WHO WILL FIND THIS REPORT USEFUL?
    • STUDY AND FORECASTING YEARS
  2. RESEARCH METHODOLOGY
    • SOURCES OF DATA
      • SECONDARY DATA
      • PRIMARY DATA
    • TOP-DOWN APPROACH
    • BOTTOM-UP APPROACH
    • DATA TRIANGULATION
  3. EXECUTIVE SUMMARY
    • MARKET SUMMARY
    • KEY FINDINGS
      • SCAFFOLD FREE IS THE FASTEST GROWING 3D CELL CULTURE TECHNOLOGY
      • STEM CELL RESEARCH IS THE WIDELY USED APPLICATION
      • BIOTECHNOLOGY AND PHARMACEUTICAL ORGANIZATIONS ARE THE MAJOR END USERS
      • REAGENTS AND CONSUMABLES ARE THE MAJOR USED COMPONENTS
  1. MARKET DYNAMICS
    • MARKET SCOPE & DEFINITION
    • MARKET DRIVERS
      • GROWING DEMAND FOR 3D CELL CULTURE PLATFORMS
      • TECHNOLOGICAL ADVANCEMENT
      • INCREASED FOCUS ON THE REGENERATIVE MEDICINE
      • RISING GLOBAL R&D INVESTMENTS IN CELL BASED RESEARCH
    • MARKET RESTRAINTS
      • EXPENSES ASSOCIATED WITH THE IMPLEMENTATION OF 3D CELL CULTURE
      • LACK OF SKILLED PROFESSIONALS
      • LACK OF CONSISTENCY IN RESULTS
    • MARKET OPPORTUNITIES
      • USAGE OF THE 3D CULTURE IN DRUG SCREENING AND ORGAN TRANSPLANTATION
      • RISE IN THE PREVALENCE RATE OF CANCER
    • MARKET CHALLENGES
      • CHALLENGES ASSOCIATED WITH DEVELOPING OPTIMIZED 3D CELL CULTURE
      • LIMITED DATA AVAILABILITY DUE TO RESTRICTED RESEARCH ON CELL CULTURE
  1. MARKET BY TECHNOLOGY
    • SCAFFOLD BASED
      • HYDROGELS
      • POLYMERIC SCAFFOLDS
      • MICROPATTERNED SURFACE MICROPLATES
    • SCAFFOLD FREE
      • HANGING DROP MICROPLATES
      • SPHEROID MICROPLATES CONTAINING ULTRA-LOW ATTACHMENT (ULA) COATING
      • MICROFLUIDIC 3D CELL CULTURE
      • MAGNETIC LEVITATIONS & 3D BIOPRINTING
    • 3D BIOREACTORS
  2. MARKET BY APPLICATION
    • CANCER
    • TISSUE ENGINEERING & IMMUNOHISTOCHEMISTRY
    • DRUG DEVELOPMENT
    • STEM CELL RESEARCH
    • OTHER APPLICATIONS
  3. MARKET BY END-USERS
    • BIOTECHNOLOGY AND PHARMACEUTICAL ORGANIZATIONS
    • RESEARCH LABORATORIES AND INSTITUTES
    • HOSPITALS AND DIAGNOSTIC CENTERS
    • OTHER END USERS
  4. MARKET BY COMPONENT
    • MEDIA
    • REAGENTS AND CONSUMABLES
  5. KEY ANALYTICS
    • PORTER’S FIVE FORCES MODEL
      • THREAT OF NEW ENTRANTS
      • THREAT OF SUBSTITUTE
      • BARGAINING POWER OF BUYERS
      • BARGAINING POWER OF SUPPLIERS
      • THREAT OF COMPETITIVE RIVALRY
    • POLITICAL & LEGAL, ECONOMIC, AND TECHNOLOGICAL ANALYSIS
    • REGULATORY FRAMEWORK
    • OPPORTUNITY MATRIX
  6. GEOGRAPHICAL ANALYSIS
    • NORTH AMERICA
      • THE UNITED STATES
      • CANADA
    • EUROPE
      • GERMANY
      • THE UNITED KINGDOM
      • FRANCE
      • SPAIN
      • ITALY
      • REST OF EUROPE
    • ASIA PACIFIC
      • JAPAN
      • CHINA
      • INDIA
      • AUSTRALIA
      • SOUTH KOREA
      • REST OF ASIA PACIFIC
    • REST OF WORLD
      • LATIN AMERICA
      • MIDDLE EAST AND AFRICA
  1. COMPANY PROFILES
    • 3D BIOTEK LLC
    • BECTON, DICKINSON AND COMPANY
    • CORNING INC.
    • EMULATE
    • GE HEALTHCARE
    • INSPHERO
    • LONZA GROUP AG
    • MERCK KGAA
    • NANO3D BIOSCIENCES, INC.
    • PROMOCELL GMBH
    • TECAN TRADING AG.
    • THERMO FISHER SCIENTIFIC INC.
    • VWR INTERNATIONAL, LLC

TABLE LIST

TABLE 1        GLOBAL 3D CELL CULTURE MARKET, BY REGION, 2019-2027 ($ MILLION)

TABLE 2        GLOBAL 3D CELL CULTURE MARKET, BY TECHNOLOGY, 2019-2027 ($ MILLION)

TABLE 3        GLOBAL SCAFFOLD BASED MARKET, BY REGION, 2019-2027 ($ MILLION)

TABLE 4        GLOBAL SCAFFOLD BASED MARKET, BY TYPE, 2019-2027 ($ MILLION)

TABLE 5        GLOBAL HYDROGELS MARKET, BY REGION, 2019-2027 ($ MILLION)

TABLE 6        GLOBAL POLYMERIC SCAFFOLDS MARKET, BY REGION, 2019-2027 ($ MILLION)

TABLE 7        GLOBAL MICROPATTERNED SURFACE MICROPLATES MARKET, BY REGION, 2019-2027 ($ MILLION)

TABLE 8        GLOBAL SCAFFOLD FREE MARKET, BY REGION, 2019-2027 ($ MILLION)

TABLE 9        GLOBAL SCAFFOLD FREE MARKET, BY TYPE, 2019-2027 ($ MILLION)

TABLE 10      GLOBAL HANGING DROP MICROPLATES MARKET, BY REGION, 2019-2027 ($ MILLION)

TABLE 11      GLOBAL SPHEROID MICROPLATES CONTAINING ULTRA-LOW ATTACHMENT (ULA) COATING MARKET, BY REGION, 2019-2027 ($ MILLION)

TABLE 12      GLOBAL MICROFLUIDIC 3D CELL CULTURE MARKET, BY REGION, 2019-2027 ($ MILLION)

TABLE 13      GLOBAL MAGNETIC LEVITATIONS & 3D BIOPRINTING MARKET, BY REGION, 2019-2027 ($ MILLION)

TABLE 14      GLOBAL 3D BIOREACTORS MARKET, BY REGION, 2019-2027 ($ MILLION)

TABLE 15      GLOBAL 3D CELL CULTURE MARKET, BY APPLICATION, 2019-2027 ($ MILLION)

TABLE 16      GLOBAL CANCER MARKET, BY REGION, 2019-2027 ($ MILLION)

TABLE 17      GLOBAL TISSUE ENGINEERING & IMMUNOHISTOCHEMISTRY MARKET, BY REGION, 2019-2027 ($ MILLION)

TABLE 18      GLOBAL DRUG DEVELOPMENT MARKET, BY REGION, 2019-2027 ($ MILLION)

TABLE 19      GLOBAL STEM CELL RESEARCH MARKET, BY REGION, 2019-2027 ($ MILLION)

TABLE 20      GLOBAL OTHER APPLICATION MARKET, BY REGION, 2019-2027 ($ MILLION)

TABLE 21      GLOBAL 3D CELL CULTURE MARKET, BY END-USER, 2019-2027 ($ MILLION)

TABLE 22      GLOBAL BIOTECHNOLOGY AND PHARMACEUTICAL ORGANIZATIONS MARKET, BY REGION, 2019-2027 ($ MILLION)

TABLE 23      GLOBAL RESEARCH LABORATORIES AND INSTITUTES MARKET, BY REGION, 2019-2027 ($ MILLION)

TABLE 24      GLOBAL HOSPITALS AND DIAGNOSTIC CENTERS MARKET, BY REGION, 2019-2027 ($ MILLION)

TABLE 25      GLOBAL OTHER END USER MARKET, BY REGION, 2019-2027 ($ MILLION)

TABLE 26      GLOBAL 3D CELL CULTURE MARKET, BY COMPONENT, 2019-2027 ($ MILLION)

TABLE 27      USAGE OF MEDIA IN DIFFERENT STAGES OF ORGANOIDS FORMATION

TABLE 28      GLOBAL MEDIA MARKET, BY REGION, 2019-2027 ($ MILLION)

TABLE 29      GLOBAL REAGENTS AND CONSUMABLES MARKET, BY REGION, 2019-2027 ($ MILLION)

TABLE 30      GLOBAL 3D CELL CULTURE MARKET, BY REGION, 2019-2027 ($ MILLION)

TABLE 31      NORTH AMERICA 3D CELL CULTURE MARKET, BY COUNTRY, 2019-2027 ($ MILLION)

TABLE 32      EUROPE 3D CELL CULTURE MARKET, BY COUNTRY, 2019-2027 ($ MILLION)

TABLE 33      ASIA PACIFIC 3D CELL CULTURE MARKET, BY COUNTRY, 2019-2027 ($ MILLION)

TABLE 34      REST OF WORLD 3D CELL CULTURE MARKET, BY REGION, 2019-2027 ($ MILLION)

 

FIGURE LIST          

FIGURE 1      GLOBAL 3D CELL CULTURE MARKET, 2019-2027 ($ MILLION)

FIGURE 2      GLOBAL 3D CELL CULTURE MARKET SHARE, BY TECHNOLOGY, 2018 & 2027 (%)

FIGURE 3      GLOBAL 3D CELL CULTURE MARKET, BY SCAFFOLD BASED, 2019-2027 ($ MILLION)

FIGURE 4      GLOBAL 3D CELL CULTURE MARKET, BY HYDROGELS, 2019-2027 ($ MILLION)

FIGURE 5      GLOBAL 3D CELL CULTURE MARKET, BY POLYMERIC SCAFFOLDS, 2019-2027 ($ MILLION)

FIGURE 6      GLOBAL 3D CELL CULTURE MARKET, BY MICROPATTERNED SURFACE MICROPLATES, 2019-2027 ($ MILLION)

FIGURE 7      GLOBAL 3D CELL CULTURE MARKET, BY SCAFFOLD FREE, 2019-2027 ($ MILLION)

FIGURE 8      GLOBAL 3D CELL CULTURE MARKET, BY HANGING DROP MICROPLATES, 2019-2027 ($ MILLION)

FIGURE 9      GLOBAL 3D CELL CULTURE MARKET, BY SPHEROID MICROPLATES CONTAINING ULTRA-LOW ATTACHMENT (ULA) COATING, 2019-2027 ($ MILLION)

FIGURE 10   GLOBAL 3D CELL CULTURE MARKET, BY MICROFLUIDIC 3D CELL CULTURE, 2019-2027 ($ MILLION)

FIGURE 11   GLOBAL 3D CELL CULTURE MARKET, BY MAGNETIC LEVITATIONS & 3D BIOPRINTING, 2019-2027 ($ MILLION)

FIGURE 12   GLOBAL 3D CELL CULTURE MARKET, BY 3D BIOREACTORS, 2019-2027 ($ MILLION)

FIGURE 13   GLOBAL 3D CELL CULTURE MARKET, SHARE BY APPLICATION, 2018 & 2027 (%)

FIGURE 14   GLOBAL 3D CELL CULTURE MARKET, BY CANCER, 2019-2027 ($ MILLION)

FIGURE 15   GLOBAL 3D CELL CULTURE MARKET, BY TISSUE ENGINEERING & IMMUNOHISTOCHEMISTRY, 2019-2027 ($ MILLION)

FIGURE 16   GLOBAL 3D CELL CULTURE MARKET, BY DRUG DEVELOPMENT, 2019-2027 ($ MILLION)

FIGURE 17   GLOBAL 3D CELL CULTURE MARKET, BY STEM CELL RESEARCH, 2019-2027 ($ MILLION)

FIGURE 18   GLOBAL 3D CELL CULTURE MARKET, BY OTHER APPLICATION, 2019-2027 ($ MILLION)

FIGURE 19   GLOBAL 3D CELL CULTURE MARKET SHARE, BY END-USER, 2018 & 2027 (%)

FIGURE 20   GLOBAL 3D CELL CULTURE MARKET, BY BIOTECHNOLOGY AND PHARMACEUTICAL ORGANIZATIONS, 2019-2027 ($ MILLION)

FIGURE 21   GLOBAL 3D CELL CULTURE MARKET, BY RESEARCH LABORATORIES AND INSTITUTES, 2019-2027 ($ MILLION)

FIGURE 22   GLOBAL 3D CELL CULTURE MARKET, BY HOSPITALS AND DIAGNOSTIC CENTERS, 2019-2027 ($ MILLION)

FIGURE 23   GLOBAL 3D CELL CULTURE MARKET, BY OTHER END USERS, 2019-2027 ($ MILLION)

FIGURE 24   GLOBAL 3D CELL CULTURE MARKET, SHARE BY COMPONENT, 2018 & 2027 (%)

FIGURE 25   GLOBAL 3D CELL CULTURE MARKET, BY MEDIA, 2019-2027 ($ MILLION)

FIGURE 26   GLOBAL 3D CELL CULTURE MARKET, BY REAGENTS AND CONSUMABLES, 2019-2027 ($ MILLION)

FIGURE 27   PORTER’S FIVE FORCE MODEL

FIGURE 28   GLOBAL 3D CELL CULTURE MARKET, REGIONAL OUTLOOK, 2018 & 2027 (%)

FIGURE 29   THE UNITED STATES 3D CELL CULTURE MARKET, 2019-2027 ($ MILLION)

FIGURE 30   CANADA 3D CELL CULTURE MARKET, 2019-2027 ($ MILLION)

FIGURE 31   GERMANY 3D CELL CULTURE MARKET, 2019-2027 ($ MILLION)

FIGURE 32   THE UNITED KINGDOM 3D CELL CULTURE MARKET, 2019-2027 ($ MILLION)

FIGURE 33   FRANCE 3D CELL CULTURE MARKET, 2019-2027 ($ MILLION)

FIGURE 34   SPAIN 3D CELL CULTURE MARKET, 2019-2027 ($ MILLION)

FIGURE 35   ITALY 3D CELL CULTURE MARKET, 2019-2027 ($ MILLION)

FIGURE 36   REST OF EUROPE 3D CELL CULTURE MARKET, 2019-2027 ($ MILLION)

FIGURE 37   JAPAN 3D CELL CULTURE MARKET, 2019-2027 ($ MILLION)

FIGURE 38   CHINA 3D CELL CULTURE MARKET, 2019-2027 ($ MILLION)

FIGURE 39   INDIA 3D CELL CULTURE MARKET, 2019-2027 ($ MILLION)

FIGURE 40   AUSTRALIA 3D CELL CULTURE MARKET, 2019-2027 ($ MILLION)

FIGURE 41   SOUTH KOREA 3D CELL CULTURE MARKET, 2019-2027 ($ MILLION)

FIGURE 42   REST OF ASIA PACIFIC 3D CELL CULTURE MARKET, 2019-2027 ($ MILLION)

FIGURE 43   LATIN AMERICA 3D CELL CULTURE MARKET, 2019-2027 ($ MILLION)

FIGURE 44   MIDDLE EAST AND AFRICA 3D CELL CULTURE MARKET, 2019-2027 ($ MILLION)

  1. MARKET BY TECHNOLOGY
    • SCAFFOLD BASED
      • HYDROGELS
      • POLYMERIC SCAFFOLDS
      • MICROPATTERNED SURFACE MICROPLATES
    • SCAFFOLD FREE
      • HANGING DROP MICROPLATES
      • SPHEROID MICROPLATES CONTAINING ULTRA-LOW ATTACHMENT (ULA) COATING
      • MICROFLUIDIC 3D CELL CULTURE
      • MAGNETIC LEVITATIONS & 3D BIOPRINTING
    • 3D BIOREACTORS
  2. MARKET BY APPLICATION
    • CANCER
    • TISSUE ENGINEERING & IMMUNOHISTOCHEMISTRY
    • DRUG DEVELOPMENT
    • STEM CELL RESEARCH
    • OTHER APPLICATIONS
  3. MARKET BY END-USERS
    • BIOTECHNOLOGY AND PHARMACEUTICAL ORGANIZATIONS
    • RESEARCH LABORATORIES AND INSTITUTES
    • HOSPITALS AND DIAGNOSTIC CENTERS
    • OTHER END USERS
  4. MARKET BY COMPONENT
    • MEDIA
    • REAGENTS AND CONSUMABLES
  5. GEOGRAPHICAL ANALYSIS
    • NORTH AMERICA
      • THE UNITED STATES
      • CANADA
    • EUROPE
      • GERMANY
      • THE UNITED KINGDOM
      • FRANCE
      • SPAIN
      • ITALY
      • REST OF EUROPE
    • ASIA PACIFIC
      • JAPAN
      • CHINA
      • INDIA
      • AUSTRALIA
      • SOUTH KOREA
      • REST OF ASIA PACIFIC
    • REST OF WORLD
      • LATIN AMERICA
      • MIDDLE EAST AND AFRICA

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